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This content was как by our users and we как good faith they have the permission to share this book. If you own the copyright to this book and it is wrongfully on our website, we offer a simple DMCA procedure to remove your секс from our site. Start by pressing the button below! Икновенпя rights reserved. Eugene S. Evelyn J. Ohayon, Robin G. Bebbington, R. Tennant, J. Faravelli, S.

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Pro Python. Immunological methods e. Molecular biological techniques are described in detail in monographs such as Molecular Cloning: A Laboratory Manual, 2nd ed. The mammalian subject can be anyone suffering from a vascular disease, including humans, dogs, cats, horses, cattle, sheep, goats and pigs.

Human subjects can be males, females, adults, children, or the elderly 65 years and older. A mammalian subject may have peripheral arterial disease, coronary artery disease, renal artery disease, Buerger's disease, atherosclerosis, or ischemia. CDR can be determined according to known methods, such as described in Ofran et al. Human mAbs are obtained by immortalizing a human Ab secreting cell e. See, for example, US patent No.

These subjects, in which the desired Ab is expressed, can then be used as donors of B-lymphocytes. These cells can then be immortalized by viral transformation for example, using EBV or by fusion with another immortalized cell, such as a human myeloma cell, according to known methods.

MAb secreted by these clonal cell lines can be purified from culture medium or body fluid e. See, for example, the methods described in US patent application No.

Since Ig contain heavy H and light L chains in the configuration of H 2 L 2 , the genes encoding each of them can be isolated separately and expressed in different vectors. Such chimeric Ab can be obtained using methods known in the art.

See, for example, Morrison et al. USA , ; Neuberger et al. Similarly, Ab can be humanized using methods known in the art. For example, mAbs with desired binding specificity can be humanized by various manufacturers or as described in US Pat. Proc Nat. USA , ; Schier et al. Gene , ; Yelton et al. Variants of the amino acid sequence Ab can be obtained by making the corresponding changes in the nucleotide sequence encoding Ab. The MAbs described herein can also be modified by conjugation with another protein e.

For example, a mAb may be conjugated to a water-soluble polymer, such as polyethylene glycol or a carbon nanotube see, for example, Kam et al, Proc. USA , See U. Patent Application No. The mAb compositions of the present invention may include only one type of mAb i.

Typically, such an administration will be parenteral e. The composition can also be entered directly into the target area, for example, by injection.

Other delivery methods, for example, liposomal delivery or diffusion from a device impregnated with the composition, are known in the art. The composition may be administered by a single bolus injection, multiple injections, or by continuous infusion for example, intravenously, or by means of peritoneal dialysis. As is well known in the medical field, the dosage for any animal or person depends on many factors, including the size of the subject, the surface area of the body, age, the particular composition to be administered, gender, time and route of administration, general health and other drugs administered at the same time.

Preferred doses range from about 0. The dose can be given systematically, for example, every hour, daily, twice a week, weekly, once every two weeks, once every three weeks or every month. Preferably, 2 or more e. The test group was also treated with MABp1 3. The two groups analyzed differences in the frequency of repeated surgical intervention on the vessels. Of the 43 subjects evaluated, 22 were in the test group and 21 were in the control group.

At this point in time, the probability that patients in the control group will experience MACE was 3 times higher than the probability for the MABp1 group odds ratio 3. During the first 15 weeks, two patients 9. At the same time, even with a higher risk at the initial level, all patients receiving MABp1 maintained vascular patency, while there was no restenosis during the week period after the intervention.

Other aspects, advantages, and modifications are within the scope of the following claims. FIELD: medicine. SUBSTANCE: group of inventions relates to medicine, namely cardiology, and can be used to prevent complications associated with vascular disease and its treatment.

EFFECT: use of inventions makes it possible to reduce the risk of restenosis and serious adverse cardiovascular events in a patient who has received or is about to receive surgical treatment of the stenosis of a blood vessel. General methodology [] Methods including traditional immunological and molecular biological techniques are described herein.

Decreased likelihood of MACE and restenosis [] The compositions and methods described herein are applicable to reduce the likelihood of the occurrence or severity of MACE occurring in a mammalian subject receiving surgical treatment for or awaiting receipt of a blood vessel stenosis, as well as to reduce the likelihood of restenosis occurring in the subject , or an increase in the time before the occurrence of restenosis in a subject. The use according to claim 2, where the monoclonal antibody is IgG1.

The use of claim 2, wherein the monoclonal antibody comprises a complementarity determining portion of MABp1. The use of claim 2, wherein the monoclonal antibody is MABp1. The use according to claim 7, where the monoclonal antibody is IgG1.

The use of claim 7, wherein the monoclonal antibody comprises a complementarity determining region from MABp1. The use of claim 7, wherein the monoclonal antibody is MABp1.