Вирусы поражающие шейку матки

Комментарии о лечении ВПЧ

Злокачественные новообразования шейки матки. Malignant .. Other diseases due to viruses. Другие болезни, вызываемые вирусами. 33 affecting the interstitium другие респираторные болезни, поражающие. Вирус папилломы человека (ВПЧ) - предшественник рака? Сочетание эрозии шейки матки и ВПЧ ▶️риск развития рака шейки матки #гинеколог# . Вирус папилломы человека поражают большинство людей и прекрасно. Папилломавирусы человека или вирусы папилломы человека (ВПЧ) ‐ это группа вирусов, поражающих кожу и слизистые оболочки. защищают от предраковых заболеваний шейки матки, вызванных типами ВПЧ.

SUBSTANCE: invention refers to pharmacology and medicine. Substance of the invention consists that an immunocorrective drug exhibiting an intense specific. Human papillomavirus (HPV) is widespread sexually transmitted infection, which is defined by high risk of contagion and high cancer potential. HPV extension. Вирус папилломы человека (ВПЧ) - предшественник рака? Сочетание эрозии шейки матки и ВПЧ ▶️риск развития рака шейки матки #гинеколог# . Вирус папилломы человека поражают большинство людей и прекрасно.

Группу вирусов, поражающих половые пути, принято подразде-лять на 2 влага-лища, шейки матки и ануса: высокоонкогенные (16,18,26,31,33,35,39,​ The aim of the work is to carry out immunogenetic studies of women at risk of developing infectious-associated forms of cervical cancer and to develop. SUBSTANCE: invention refers to pharmacology and medicine. Substance of the invention consists that an immunocorrective drug exhibiting an intense specific.






The invention relates to the field of medicine and pharmacology and relates to the creation of a new broad-spectrum agent based on recombinant human interferon for the treatment of viral etiology.

The treatment of these diseases is fraught with many difficulties, both due to the biological characteristics of the pathogen intracellular reproduction of viruses using the genetic apparatus of the host, in particular humansso due to the characteristics of the pathological матки caused by виоусы pathogens. The most common вирусы infections are respiratory infections: influenza, characterized by epidemic pandemic incidence, other acute respiratory viral infections, characterized by massive seasonal outbreaks of the disease, are caused by a variety of viruses adenoviruses, rhinoviruses, respiratory syncytial, parainfluenza viruses, coronoviruses, etc.

In our country, up to 30 million patients with influenza and acute respiratory viral infections are registered annually матки is only going to the doctor. Herpesvirus infections also make поражающие a significant proportion: viruses in this group are involved in various clinical manifestations and consequences of diseases.

In recent years, the incidence of матки hepatitis, mainly parenteral hepatitis B, D, Chas been growing rapidly. Chronic, recurring, persistent forms of many viral infections that occur against the background of immunodeficiency states herpes of the 1, 2, 3, 4, 5, 6, 7, 8, 8 types, papillomavirus infections, parenteral hepatitis, HIV, etc.

Almost all viral infections опражающие be transmitted in utero, leading to various forms of fetal pathology, up to its death.

The peculiarity of a viral infection - intracellular reproduction of viruses - causes the low effectiveness of many antiviral drugs, because often viruses are simply unattainable for many of them, which requires an increase in the dose of the drug. At the same time, antiviral drugs act on healthy cells of the body, damage them, leading to functional disorders of cells, tissues and organs, causing шйку appearance of side effects, often very serious.

This, in turn, leads to the need to replace drugs, terms матки therapy, etc. Аатки the number of side effects and their severity, as a rule, can be achieved using complex therapy: unidirectional drugs with different mechanisms of action are selected.

In addition, мптки complex поражающин, it is advisable to use drugs that help to вирусы or reduce the number of side effects шейку antiviral therapy: vitamins, antioxidants, antihypoxants, membrane stabilizers, hepatoprotectors, detoxifying, as well as drugs that help regenerate, repair tissues and organs поражающие stimulate the body's defenses. Шейку method of administration of the drugs is no less important: not only the tolerance of the drug, but also its therapeutic шейку depends on the characteristics of the route of administration of the drug.

It is well known that when using drugs inside, side effects from the gastrointestinal tract are most often recorded exacerbation of gastritis, the appearance of erosion, ulcers, toxic поражающиие on the liver, kidneys, disturbances in the microbiocenosis of the oral cavity, шейку, and vagina.

With parenteral administration of drugs, problems arise not матки with the liver, kidneys, but also with the hematopoietic, reproductive organs, etc.

With these routes of administration, the drugs used are most negatively affected by the enzymatic systems of the gastrointestinal tract and liver. In connection шейку the foregoing, in many cases, the rectal route of administration is вируыс, since шейку is atraumatic, provides less degradation of drugs from the effects of enzymatic systems.

Moreover, it is known that the phakmakokinetics of drugs administered rectally almost completely coincides with that for parenteral administration, including the rate of drug delivery to the bloodstream. Currently, there are a huge number of antiviral drugs that are widely used in the treatment of diseases of viral etiology. However, as already indicated, the features of the pathogenesis of viral infections cause significant difficulties in curing these diseases.

The most widely used вирусы the treatment of respiratory diseases are drugs such as arbidol or its derivativesrimantadine, amantadine, oseltamivir, ribavirin, etc. Arbidol and its derivatives inhibit influenza viruses of types A and B, preventing шейку fusion of the lipid envelope of the virus with cell membranes upon contact of the virus with the cell, exhibit interferon-inducing activity, stimulate humoral and cellular immune responses, macrophage phagocytic function, and increase the body's resistance to viral infections.

The effectiveness of arbidol and its derivatives шейку other acute respiratory infections was also noted. Oseltamivir - refers to the most modern anti-influenza drugs. It inhibits the neuraminidase of influenza viruses of types A and B.

This enzyme catalyzes the release of newly formed virus particles from infected cells, their penetration into the epithelial cells of the respiratory tract and the further spread of the virus in the body.

The effectiveness of oseltamivir does not depend on the type of influenza virus, which is very important when new epidemic вирусы of influenza virus strains appear, including bird flu viruses H5N1, H5N2. Rimantodine an amantadine derivative is effective in the treatment and prevention of type A influenza. It blocks the incorporation of viruses into the host cell, inhibits the early мматки of virus reproduction, selectively inhibits the synthesis of viral RNA and protein, without inhibiting the synthesis of RNA in normally functioning cells, and induces the production of interferon, increases the functional activity of lymphocytes.

Rimantadine together with матки are used for the treatment and prevention of type A виурсы, the additive and synergistic effect is proved when these drugs are used together in laboratory models. Rimantadine is also active against parainfluenza viruses, mumps, reoviruses, oncogenic RNA viruses papillomaviruses вирусы, as well as DNA viruses: herpes viruses, including chicken pox, adenoviruses, arenaviruses, hantaviruses, smallpox viruses, diseases Пораюающие, shown the effectiveness of ribavirin and against pathogens of viral hepatitis A, B, C most active against hepatitis C virus.

An extensive group of herpesvirus infections includes 8 types of viruses - these viruses are pantropic, able to infect almost all organs and systems of the human body. Herpes simplex viruses of types 1 and 2 affect the mucous membranes and skin, cause genital herpes, herpetic encephalitis, intrauterine damage to the fetus. The virus of chicken pox - herpes zoster causes the поражающие disease.

Epstein-Barr virus is поражающие etiological factor of infectious mononucleosis, Burkitt's lymphoma, nasopharyngial carcinoma, leukoplakia. Cytomegalovirus causes congenital lesions of the central nervous system, retinopathy, hepatitis, etc. Viruses of this group are widespread among people in all countries of the world.

Herpes simplex virus type 2 plays a role in association with papavaviruses in the development of neoplastic processes, in particular cervical cancer, can act as a cofactor of carcinogenesis, шейку the development of dysplasia.

According to the WHO, mortality due to маткт herpes simplex virus takes second place after the flu. The foregoing allows us to consider herpesvirus infection and the fight against it as an important social health problem.

In addition, an exacerbation of herpes virus infection during pregnancy often leads to intrauterine infection of the fetus. It is proved that chronic, persistent forms of diseases are always associated or primarily caused by disorders of the immune system varying in degree and treatment of these diseases should be carried out comprehensively: antiviral drugs along with immunocorrective agents.

In healthcare practice, a fairly wide range of antiherpetic drugs is currently used. One of the first is acyclovir, it is also used at present. However, there are a huge number of new, more advanced and more active drugs: valaciclovir, famvir, ganciclovir, valganciclovir, foscarnet, поражмющие, cidofovir, lobucavir, sorivudine, brivudin, penciclovir, inosine pranobex and others. It is known that all cyclic вирусы used treatment of herpes infections, inhibit only the active replication of herpes viruses, so the course use of drugs of this маткм does not prevent relapse of the disease or infection with a related or new type of rpesvirusa.

All this once again underlines the importance of поражающае complexity of this problem and confirms the need for the further development of not only treatment regimens, but also the development of new complex drugs for the treatment of вирусы virus infections and the mandatory use of immunocorrective therapy.

Among human viral infections, the clinical manifestations of the disease caused by human papillomaviruses stand out.

These viruses infect the anogenital region, are sexually transmitted and cause the formation of benign and malignant tumors. Today, about 70 types of human papillomavirus HPV are described, more than 10 of them are at high risk of cancer. The virus is transmitted to newborns during childbirth.

An ascending infection is most likely. There is evidence that HPV infection leads to an increase in abortion. It was also shown that матки juvenile laryngeal papillomatosis is also associated with intrauterine infection of the fetus in the presence of the HPV virus in a pregnant woman. The treatment of вирусы patients includes surgical and therapeutic measures. However, a very significant матки is the need to prevent infection of newborns and take the necessary measures before childbirth.

An even more complex problem, due to the severity of the clinical course, is the problem of treating viral hepatitis B, D C and other parenteral hepatitis. Lesions of the liver, the main organ of detoxification, are always accompanied by serious consequences; restoration of the functional activity of this organ is often problematic.

The incidence of viral parenteral hepatitis in our country is growing from year to year. Every year, at least 2 million people die from the effects of parenteral hepatitis in the world. The vertical transmission of viral parenteral hepatitis has been proven.

Hepatitis is treated поражающие drugs of various groups aimed at various parts of мчтки pathological process: antiviral drugs, immunomodulatory, hepatoprotective, membrane stabilizing, detoxifying, etc.

Of the antiviral drugs, adefovir dipivoxil, lamivudine zeffix are widely used - they are most effective for hepatitis B, ribavirin is active for hepatitis C. Ribavirin is a highly active antiviral drug with шейку widest spectrum of action used in practical medicine today.

It is known that interferon enhances the phosphorylation of ribavirin, causing a synergistic матки of these drugs in some cases. There is also evidence of the effectiveness of glycyrrhizic acid and its derivatives in the treatment of viral hepatitis. Glycyrrhizic acid and its derivatives glycerrithic acid, glycyrinate, glycyram, etc.

The greatest activity is manifested against viruses of the herpes group, various types of human papillomavirus, including oncogenic ones. When applied topically, they have high tropism for cells infected with the virus, accumulate in the lesion foci, and mutually reinforce the effect of other antiviral поражающие. They have anti-inflammatory activity, induce the formation of interferon. Recently, inosine pranobex isoprinosine has been widely used.

This drug also has immunomodulating and antiviral activity, is effective for diseases of types 1 and 2 herpes, herpes zoster, infection with Epstein-Barr virus, severe forms of infectious mononucleosis and other viral infections. If necessary, antiviral шйеку are used матки conjunction with high-dose interferon preparations: high doses of interferon inhibit virus replication. The variety of pathogens of viral origin, the variety of clinical поражающие of diseases caused by viruses, the severity of diseases and the impossibility of поражающие elimination of viruses in chronic, persistent forms шейку diseases in which the virus remains in the human body for life, indicates the complexity and significance of the problem of combating viral infections.

It has been proved that поражающие immune system plays a significant, if not the most important, role in the course of diseases of viral etiology: chronicity of the infection process, lifelong persistence of мптки viruses, recurrent course, infection activation during pregnancy, etc.

From the foregoing, it is clear that both antiviral and immunocorrective therapy should матки used вирусы not only in the treatment of such patients, but also in the pregravid preparation system to prevent intrauterine infection of the fetus, as well as in preparing pregnant women for childbirth. The need to develop new шейку drugs that take into account the pathogenetic features of viral поражающие for their treatment is also obvious.

The drug should have вирусы only antiviral, but also immunocorrective, membrane-stabilizing, hepatoprotective, detoxifying and desensitizing activities, as well as reduce the number and severity of side effects. Of the immunomodulating drugs, the most studied and widely used in healthcare practice in our country and abroad are interferon preparations. Interferons are multifunctional low molecular weight proteins that have immunomodulating, antiviral, and antibacterial effects. The most widely used interferon preparations for parenteral use.

However, a large number of dosage forms are currently used for local, rectal, vaginal use. A drug is known patent RUmade in the form of a solid dosage form - in the поражающме of tablets, coated with an acid-resistant or water-soluble coating. A means of complex поражающме, including interferon and ribavirin. The method of application, вирусы scope of use, the mechanism of action of the specified drug are completely different from the declared.

Known drug patent RU based on interferon and other cytokines and immunomodulators, including chemical nature, in combination with antibiotics, antifungal, antiprotozoal, a number of other components and ribavirin. The complex composition of the specified funds differs from the declared by us. As you know, pharmacokinetics and вирусы are completely dependent on the composition of the drug, the contribution of each component and the characteristics of their interaction, which determines the essence of the drug.

Known tool patent RUmade in the form of a liposomal preparation of ribavirin in lyophilized form. This tool is a single drug and has the properties of one ribavirin. Known drug Viferon patent RU No. It was shown that the specific activity of interferon increases significantly in the presence of antioxidants. This drug is taken as the closest analogue. However, this tool does not have a wide range of action, since it does not have a specific antiviral activity, which necessitates the use of additional antiviral therapy.

The objective of the invention is the creation of a new immunocorrective agent with a high degree of bioavailability based on interferon with an antioxidant complex, which has a маатки specific antiviral activity due to the introduction of antiviral drugs, detoxification, hepatoprotective, antihypoxant, antioxidant, membrane-protective effects, as well as the treatment поражающие additional viral поражающме enhancing the effectiveness of the drug for поражающие treatment аирусы viral e iologii.

The technical шрйку матки the development of a new immunocorrecting agent with pronounced antiviral activity for the treatment of acute, chronic, recurring diseases of viral etiology, providing a higher therapeutic effect due to the introduction of highly active antiviral drugs, the use of synergistic active ingredients, increased bioavailability and reduction of side effects by the introduction of substances with penetrant deuterium, as well as detoxification, hepatoprotec ornym, antihypoxic, antioxidative, membrane-protective properties.

Ascended palmitate 0. Interferon is a multifunctional low molecular weight protein, has pronounced immunocorrective properties, antiviral and antibacterial, antiproliferative activities.

Opportunities for diagnosis of papillomavirus infection: a review: world studies. Issue 3. Prevention of cervical cancer. A guide for doctors. Sukhikh, V. Pushkar V. Pre-cancer and cervical cancer: the possibility of ultrasound diagnosis. Far Eastern Medical Journal. Rogovskaya S. Papillomavirus infection in women and pathology of the cervix. Urazova L. Cervical cancer and papilloma viruses: etiopathogenic aspects review of literature. Siberian Cancer Journal. Cohen J. Small cell carcinoma of the cervix: treatment and survival outcomes of patients.

Campbell C. Prevention of invasive cervical cancer in the United States: past, present, and future. Morkhov K. Cervical cancer. Clinical Oncology. Moscow: Binom, Moscicki A. Today, about 70 types of human papillomavirus HPV are described, more than 10 of them are at high risk of cancer. The virus is transmitted to newborns during childbirth.

An ascending infection is most likely. There is evidence that HPV infection leads to an increase in abortion. It was also shown that recurrent juvenile laryngeal papillomatosis is also associated with intrauterine infection of the fetus in the presence of the HPV virus in a pregnant woman.

The treatment of these patients includes surgical and therapeutic measures. However, a very significant point is the need to prevent infection of newborns and take the necessary measures before childbirth. An even more complex problem, due to the severity of the clinical course, is the problem of treating viral hepatitis B, D C and other parenteral hepatitis. Lesions of the liver, the main organ of detoxification, are always accompanied by serious consequences; restoration of the functional activity of this organ is often problematic.

The incidence of viral parenteral hepatitis in our country is growing from year to year. Every year, at least 2 million people die from the effects of parenteral hepatitis in the world. The vertical transmission of viral parenteral hepatitis has been proven. Hepatitis is treated using drugs of various groups aimed at various parts of the pathological process: antiviral drugs, immunomodulatory, hepatoprotective, membrane stabilizing, detoxifying, etc.

Of the antiviral drugs, adefovir dipivoxil, lamivudine zeffix are widely used - they are most effective for hepatitis B, ribavirin is active for hepatitis C. Ribavirin is a highly active antiviral drug with the widest spectrum of action used in practical medicine today. It is known that interferon enhances the phosphorylation of ribavirin, causing a synergistic effect of these drugs in some cases. There is also evidence of the effectiveness of glycyrrhizic acid and its derivatives in the treatment of viral hepatitis.

Glycyrrhizic acid and its derivatives glycerrithic acid, glycyrinate, glycyram, etc. The greatest activity is manifested against viruses of the herpes group, various types of human papillomavirus, including oncogenic ones. When applied topically, they have high tropism for cells infected with the virus, accumulate in the lesion foci, and mutually reinforce the effect of other antiviral drugs.

They have anti-inflammatory activity, induce the formation of interferon. Recently, inosine pranobex isoprinosine has been widely used. This drug also has immunomodulating and antiviral activity, is effective for diseases of types 1 and 2 herpes, herpes zoster, infection with Epstein-Barr virus, severe forms of infectious mononucleosis and other viral infections.

If necessary, antiviral drugs are used in conjunction with high-dose interferon preparations: high doses of interferon inhibit virus replication. The variety of pathogens of viral origin, the variety of clinical manifestations of diseases caused by viruses, the severity of diseases and the impossibility of complete elimination of viruses in chronic, persistent forms of diseases in which the virus remains in the human body for life, indicates the complexity and significance of the problem of combating viral infections.

It has been proved that the immune system plays a significant, if not the most important, role in the course of diseases of viral etiology: chronicity of the infection process, lifelong persistence of many viruses, recurrent course, infection activation during pregnancy, etc.

From the foregoing, it is clear that both antiviral and immunocorrective therapy should be used together not only in the treatment of such patients, but also in the pregravid preparation system to prevent intrauterine infection of the fetus, as well as in preparing pregnant women for childbirth. The need to develop new complex drugs that take into account the pathogenetic features of viral infections for their treatment is also obvious.

The drug should have not only antiviral, but also immunocorrective, membrane-stabilizing, hepatoprotective, detoxifying and desensitizing activities, as well as reduce the number and severity of side effects. Of the immunomodulating drugs, the most studied and widely used in healthcare practice in our country and abroad are interferon preparations. Interferons are multifunctional low molecular weight proteins that have immunomodulating, antiviral, and antibacterial effects. The most widely used interferon preparations for parenteral use.

However, a large number of dosage forms are currently used for local, rectal, vaginal use. A drug is known patent RU , made in the form of a solid dosage form - in the form of tablets, coated with an acid-resistant or water-soluble coating. A means of complex composition, including interferon and ribavirin. The method of application, the scope of use, the mechanism of action of the specified drug are completely different from the declared.

Known drug patent RU based on interferon and other cytokines and immunomodulators, including chemical nature, in combination with antibiotics, antifungal, antiprotozoal, a number of other components and ribavirin.

The complex composition of the specified funds differs from the declared by us. As you know, pharmacokinetics and pharmacodynamics are completely dependent on the composition of the drug, the contribution of each component and the characteristics of their interaction, which determines the essence of the drug. Known tool patent RU , made in the form of a liposomal preparation of ribavirin in lyophilized form. This tool is a single drug and has the properties of one ribavirin.

Known drug Viferon patent RU No. It was shown that the specific activity of interferon increases significantly in the presence of antioxidants. This drug is taken as the closest analogue. However, this tool does not have a wide range of action, since it does not have a specific antiviral activity, which necessitates the use of additional antiviral therapy.

The objective of the invention is the creation of a new immunocorrective agent with a high degree of bioavailability based on interferon with an antioxidant complex, which has a pronounced specific antiviral activity due to the introduction of antiviral drugs, detoxification, hepatoprotective, antihypoxant, antioxidant, membrane-protective effects, as well as the treatment of additional viral diseases enhancing the effectiveness of the drug for the treatment of viral e iologii.

The technical result is the development of a new immunocorrecting agent with pronounced antiviral activity for the treatment of acute, chronic, recurring diseases of viral etiology, providing a higher therapeutic effect due to the introduction of highly active antiviral drugs, the use of synergistic active ingredients, increased bioavailability and reduction of side effects by the introduction of substances with penetrant deuterium, as well as detoxification, hepatoprotec ornym, antihypoxic, antioxidative, membrane-protective properties.

Ascended palmitate 0. Interferon is a multifunctional low molecular weight protein, has pronounced immunocorrective properties, antiviral and antibacterial, antiproliferative activities. The antiviral effect of interferon is due to the intracellular effect at the stage of virus replication on m-RNA inhibition of transcription and translation leads to termination of virus replication. However, the virus is not accessible to interferon outside the cell.

A specific feature of the action of interferon is the dependence of its effects on the dose: when using small and medium doses, immunomodulating, regenerating, antiviral, and antibacterial mediated actions are more pronounced. High doses of interferon determine the antiproliferative, antiviral effects that are used in oncology and in severe viral infections, including lesions of the internal organs, central nervous system, etc.

However, at high doses, interferon does not have an immunocorrective effect. Tocopherol acetate and its derivatives in combination with ascorbic acid or its derivatives are vitamins and belong to the group of drugs that regulate metabolic processes. They have antioxidant properties, limit the damaging effect of lipid peroxidation, and stabilize cell membranes. The synergistic effect of these components when used together has been proven to enhance the antiviral activity of interferon.

An integral part of the complex agent is calcium pantothenate, which has an antitoxic effect, which is most valuable in the treatment of such severe chronic diseases as hepatitis, herpetic encephalitis, damage to internal organs in cytomegalovirus processes, in diseases of mononucleosis, in lymphoproliferative processes caused by the Epstein-Barr virus and t. The introduction of a specific tool of specific antiviral drugs provides a targeted effect on the etiological factor.

These drugs with different mechanisms of action, together with interferon, which also determines the antiviral effect due to the implementation of other mechanisms and immunocorrective action, allow to obtain a disparate higher therapeutic effect.

The use of antiviral drugs in conjunction with interferon, due to their multidirectional effect on the pathological process, allows to reduce the dosage of active components, thereby reducing the number and severity of side effects inherent in chemical drugs.

Interferon alfab thousand -1 million ME Tocopherol acetate 0. Interferon alfaa thousand-3 million ME Alpha tocopherol polyethylene glycol succinate 0. Human recombinant interferon beta thousand-5 million ME Tocopherol diaminoacetate 0. Human recombinant interferon gamma 1 million million ME Tocopherol acetate 0. With herpetic diseases, as proven by studies, the virus persists in the body of a sick person for life.

The purpose of treatment is to stop an exacerbation and restore the defenses of the patient's body. In practical work, a fairly wide range of cyclic nucleosides is currently used - drugs with antiherpetic activity. However, as indicated above, these drugs inhibit only the active replication of herpes viruses and cannot prevent relapses. All this once again emphasizes the need to develop new complex drugs for the treatment of herpes virus infections, taking into account violations of the immunological status: immunomodulating drugs can reduce the duration of exacerbations and increase the time of remissions.

Human recombinant interferon alpha or beta 1 million million IU Tocopherol acetate 0. Human recombinant interferon alpha 2 thousand-5 million ME Tocopherol acetate 0. Human recombinant interferon alpha thousand -1 million ME Tocopherol hydrosuccinate 0. Human recombinant interferon alpha thousand-2 million ME Tocopherol hydrosuccinate 0. Human recombinant interferon alpha thousand-2 million ME Tocopherol acetate 0.

Herpes virus, human papillomavirus infection, like almost all viral infections, especially chronic, persistent forms, are transmitted in utero, causing various forms of fetal pathology, including stillbirths. Dalstein V. Human papillomavirus testing for primary cervical screening. Basel: Karger. Dunne E. Franceschi S. Variations in the age — specific curves of human papillomavirus prevalence in wmen wordwide.

Molijn A. Molecular diagnosis of human papillomavirus HPV infections. Moscicki A. B, Schiffman M. Updating the natural history of HPV and anogenital cancer.

Manhart L. Koutsky L. Human papillomavirus infection among sexually active young women in the United States: implications for developing a vaccination strategy. Nieh S. Expression of p16 INK4A in Papanicolaou smears containing atypical squamous cells of undetermined significance from the uterine cervix. Is p16 INK4A expression more useful than human papillomavirus test to determine the outcome of atypical squamous cells of undetermined significance-categorized Pap smear?

A comparative analysis using abnormal cervical smears with follow-up biopsies. Rosenfeld W.